About Conolidine alkaloid for chronic pain
Most recently, it has been discovered that conolidine and the above derivatives act on the atypical chemokine receptor 3 (ACKR3. Expressed in equivalent areas as classical opioid receptors, it binds to a big selection of endogenous opioids. Contrary to most opioid receptors, this receptor functions like a scavenger and would not activate a second m